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Several meta-analyses showed that L-carnitine supplementation improved steatosis and NASH (67) and carnitine supplementation in NAFLD patients could reduce AST, ALT, TG, and HOMA-IR (95)

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Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]

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Current research also confirmed the possible interaction among AMPK/SIRT1, autophagy and NLRP3 inflammatory corpuscle pathway and their role in the potential anti-inflammatory neuroprotective effect of Liraglutide (Ammar et al., 2022)